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Relatively little is known about the pathway leading to the presentation of glycolipids by CD1 molecules. Here we show that the adaptor protein complex 3 AP-3 is required for the efficient presentation of glycolipid antigens that require internalization and processing. AP-3 interacts with mouse CD1d, and cells from mice deficient for AP-3 have increased cell surface levels of CD1d and decreased expression in late endosomes.
Furthermore, AP-3—deficient mice have a significantly reduced NKT cell population, although this is not caused by self-tolerance that might result from increased CD1d surface levels. These data suggest that the generation of the endogenous ligand that selects NKT cells may also be AP-3 dependent.
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John R. Funeral Home. Funeral Chapel. Funeral Centre. Quinte Funeral. Memorial Candle Tribute From. In Memory of. Aubrey Robert Woadden. Subscribe to Updates. Robert Woadden of Campbellford and formerly of Toronto in his 88th year. Son of the late Algeron and Frieda Woaden. Predeceased by his brother Derek Woadden. Robert will be missed by his matchmaker and cairn terrier, Baxter.
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Vα14i NKT cell hybridomas ,. , and 3C3 and non-Vα14i NKT cell hybridoma 24 were described pre- The MATCHMAKER. GAL4 Two-Hybrid System 3.
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